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KMID : 0357920040380050319
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Korean Journal of Pathology
2004 Volume.38 No. 5 p.319 ~ p.323
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Expression of Anaphase Promoting Complex (APC) and APC Regulatory Proteins in Invasive Ductal Carcinoma Associated with Paget´s Disease
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Park Kwang-Hwa
Yang Woo-Ick
Kang Yup
Yi Sang-Yeop
Lee Kwang-Gil
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Abstract
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Background: Oncogene expression in Paget´s disease of the breast is not well known. To characterize invasive ductal carcinoma associated with Paget´s disease, we studied expression of anaphase promoting complex (APC) with its regulatory proteins.
Methods: Immunohistochemical stainings were done with 10 cases of invasive ductal carcinoma associated with Paget´s disease for APC, pituitary tumor transforming gene (PTTG), cyclin B1, p53, cyclin D1, and c-erbB-2. The expressions of these markers in Paget´s disease were compared with those in the associated with carcinoma.
results: APC, PTTG, cyclin B1, and c-erbB-2 were positive in all of the cases with both Paget´s disease and underlying carcinoma. p53 was expressed in Paget´s disease of 6 cases (60%) and in carcinoma of 7 cases (70%). Cyclin D1 was positive in Paget´s disease of 8 cases (80%) and in carcinoma of 9 cases (90%).
Conclusions: Breast carcinomas with Paget´s disease seem to be distinguished by the high expression of APC, cyclin B1, PTTG, c-erbB2, and cyclin D1 in contrast to breast cancers without Paget´s disease. Furthermore, the similar expression patterns of APC and APC regulatory proteins in both Paget´s disease and underlying breast cancer support the epidermotropic theory as its pathogenetic mechanism.
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KEYWORD
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Paget´s disease, Breast cancer, Anaphase Promoting Complex, Cyclin B1, PTTG
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